Based on cell surface expression markers and specialized function, T cells are divided into the classic dichotomy of CD4 + and CD8 + T cells. T cells are a central component of protective immunity to severe pneumonia ( Chen and Kolls, 2013). Optimal therapies for severe pneumonia must address both pathogen and host, and a comprehensive characterization of the innate and adaptive immune response during severe pneumonia is a critical step toward achieving that goal. Thus, leveraging non-traditional strategies focusing on host-derived immune mechanisms that promote restoration of tissue architecture and physiological function are critical for improved patient outcomes and survival ( Theuretzbacher and Piddock, 2019). Furthermore, even after receiving optimal antimicrobial therapy, mortality remains exceedingly high for patients with Gram-negative pneumonia ( Feng et al., 2019). Successful resolution of any severe infectious disease requires a multipronged approach to management, but work in severe pneumonia has primarily focused on developing therapeutics that target specific pathogens. Four of these six hypervirulent pathogens are Gram-negative bacteria, underscoring the critical need to address gaps in the treatment of lower respiratory tract infection from these pathogens. A cohort of nosocomial pathogens with significant multi-drug resistant (MDR) and extensively drug resistant (XDR) characteristics are grouped together with the acronym, ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp), due to their ability to ‘escape’ traditional antimicrobial therapy ( Mulani et al., 2019). Despite advances in diagnosis and management of severe pneumonia, it remains associated with high rates of mortality, prolonged hospitalizations and substantial healthcare expenditures ( Torres et al., 2021). Gram-negative bacteria are a leading cause of severe hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP), which can progress to acute respiratory distress syndrome (ARDS), multi-organ failure, and death ( Jean et al., 2020). We highlight key factors in these responses that have potential for therapeutic targeting, as well as the gaps in current knowledge to be focused on in future work. In this review, we focus on the adaptive T cell responses to pneumonia induced by Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Adaptive immunity plays a pivotal role in modulating these processes, thus affecting the incidence and severity of pneumonia. Hence, an alternative approach is to focus on the disease tolerance components that mediate immune resistance and enhance tissue resilience. Despite advances in diagnosis and treatment, the rise of multidrug-resistant organisms and hypervirulent strains demonstrates that there will continue to be challenges with traditional treatment strategies using antibiotics. Pneumonia is one of the leading causes of morbidity and mortality worldwide and Gram-negative bacteria are a major cause of severe pneumonia.
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Dometic Air Conditioner Compressor Start Capacitor Kit (After-Market Kit) 3310727. VEXUNGA 5uF 370/440VAC 50/60Hz CBB65 CBB65A Oval Run Start Capacitor 5 MFD 370V/440V Air Conditioner Capacitors for AC Unit Fan Motor Start or Pool Pump or Air … Dometic™ 3317937. 017 Air Conditioner Motor Capacitor 55/15 MFD. Check us out at How to Test an RV Air Conditioner Capacitor. It ram 30-40 X throughout the d … read more Jan 11, 2022. There isn't room in the enclosure to replace with two capacitors of the exact value. Our intent is to provide you with a guideline of checks to make, Run Capacitor 5. In order to kick on, the thermostat temperature must be set to a lower temperature than the inside of the RV. The Dometic air conditioner units are sealed therefore they cannot be recharged with refrigerant. RV Air Conditioner Maintenance Tips The capacitor on many AC units may start both the fan and the compressor. I have a Duotherm roof AC unit model #59516. Custom Wrap-Around Shroud And Carbon Steel Base Add Strength, Protection And Durability. The Cuddy II is 12V DC-powered and draws power gently at startup for a … The information contained in this manual can be used to install EasyStart on most Dometic brand air conditioning units. difference between the supply air temperature and the return air temperature which should be close to a 20 degree split. The wire on the hard start capacitor connected to the PTCR goes to the same connector as the red wire and the other wire goes to the yellow one. Capacitors can sustain damage from excess power and will also wear down to the point where they can no longer hold a charge. For over a decade now, Dometic has been supplying air-conditioning units to the RV industry. Polar … Dometic Air Conditioner Compressor Start Capacitor 3310727. The capacitor sends a regular series of jolts to keep the motor running. I have the three wires to the compressor, C S R. ️Dometic Air Conditioner Capacitor for 15000 BTU Units - 3311541. These Videos are all part of our Training Series on HVACR Service, Installation, Preventative Maintenance, General Knowledge, and Tips. 015 no longer available replaced with B11-365. The 14-1/4" x 14-1/4" (–1/8") open-AIR CONDITIONER This is a Dometic Air Conditioner replacement 'Motor Run' capacitor. This method is practical and is a composite of two different test practices combined –. If the capacitor does not act as described it is defective and needs to be replaced. Look through the vents for the fan on top of the unit. Quick view Compare Dometic Air Conditioner Capacitor 3312195. RV AC unit (Dometic 13500 BTU) low speed runs and cools. After all, Dometic is a trusted, big name brand with years of products and pedigree behind them. Check the capacitors if the AC compressor has difficulty starting. For more information, visit ac capacitor test. The ICON replacement Brisk Air (Old Style) has the extra 2 inches molded as one piece and the rear enclosed for added durability and protection.WARNING: This product may contain one or more chemicals known in the State of California to cause cancer and/or birth defects or other reproductive harm. You should always confirm measurements before purchasing.The original Brisk Air has a 2" grey band attached along the bottom and on some the rear side is left open. If your air conditioner model number ends in. Fits Brisk Air (Old style) air conditioners.Buy an Icon shroud and you'll have complete peace of mind, knowing that your shroud is designed to last.UV resistant material, thicker and stronger than the originals.These aftermarket replacement air conditioner shrouds are constructed of high-impact. Icon Air Conditioner Shroud for Dometic Duo Therm BriskAir Old Style, Polar White.Backed by a limited lifetime warranty, Fits BriskAir new style air conditioners. Buy an Icon shroud and you'll have complete peace of mind, knowing that your shroud is designed to last. These aftermarket replacement air conditioner shrouds are constructed of high-impact UV resistant material, thicker and stronger than the originals. Icon Air Conditioner Shroud for Dometic Duo Therm BriskAir New Style, Polar White. Get chord diagrams and finger placement for every chord variation in any position.Interact with over 5000 guitar chords by dragging your finger across the diagram to hear the chord before you play.All you need is the Fender Tune app and your instrument.ĭiscover new sonic possibilities with Fender’s dynamic guitar chord library which creates any chord pattern, with multiple shape variations, anywhere on the neck. Get more out of your practice with interactive guitar chords and scales, built-in customizable drum beats, advanced precision tuning capabilities, a metronome and more. Looking for more than a standard guitar tuner? For a limited time, sign-up to gain full access to Tune Plus - the largest suite of FREE guitar-playing resources in a mobile app. INTRODUCING TUNE PLUS: THE ULTIMATE ALL-IN-ONE PRACTICE TOOLKIT Preset Tunings - 26 tunings available, including: Standard (EADGBE), Open G, Drop D, Open D and Drop C.Ĭustom Tunings - Create your own custom tunings and save to your Fender Connect personal profile for easy access. Manual Tune Mode - Tap a string on the interactive Fender headstock to hear the note and tune your acoustic guitar, electric guitar, bass or ukulele.Ĭhromatic Mode - The tuner recognizes each of the 12 chromatic (semitone) steps of the equal-tempered scale, allowing you to tune to any note on the scale. A string-by-string diagram guides the selected tuning. Accurately tune your instrument with Fender Tune’s easy-to-use interface, perfect for all musicians from beginners to pros.Īuto-Tune Mode - Pluck a string and the tuner listens to the note to guide you to a perfect pitch. Stay in tune at ! - Scott ( Administrator of Get-tuned.Fender Tune is the 5-star rated, precision tuner app for guitar, bass and ukulele from the most trusted name in guitars, Fender®. Actually I have already updated the Online Bass Guitar Tuner and the Online Ukulele Tuner, so you can check that out to see what is to come for all the instruments. Good news folks, I am working on totally revamping all of the online tuners so they have better tones and also the option to select a computer generated sine wave tones that produce a perfect pitch. I'm starting to streamline the design of this website to make it a little more user friendly and cleaner. It took a while and a lot of programming but I finally did it! Ok enough talking, check out the New Online Instrument Tuner. Scott ( Administrator of )Ģ0 August 2010 - Good news, After non-stop requests for the past 5 years or so, I finally finished an online instrument tuner that essentially turns your computer into a giant super instrument tuner that detects pitches from your instrument through a microphone. Everyone has bad breath one time or another so I think some of you might find it useful. Scott ( Administrator of )ġ4 July 2011 - This doesn't have anything to do with but I have launched a new website. Other than that it is fully functional and ready to go. This is the first version and currently it might flicker a little as it ticks, but we are working on the problem and it should be fixed soon. It allows you to change the tempo, the sound of the tick, and also if you want an accent beat to signify the beginning of the measure. This online metronome will help you stay on tempo while practicing or playing musical instruments. Scott ( Administrator of )ĥ December 2011 - Having received many requests for one over the years, is happy to announce our new Online Metronome. This tuner is similar to the online tuners we have online but now you will not have to visit this website or have internet access to get tuned! This single app is also able to tune various stringed instruments, so you don't have to buy a new app for each new instrument. 10 October 2012 - You can now get tuned on your mobile devices with the new Get-Tuned Instrument Tuner App available for Apple and Android devices. These lighthearted resolutions might make your work day feel a little more fun. I will always drink from my human's water glass when they aren't looking.įunny Work-Related New Year’s ResolutionsĪssuming you have a standard forty-hour work schedule, you spend nearly a quarter of your week at work.I will fall asleep on my human so they cannot move for the rest of the day.I will demand only wet food and refuse the rest.I will tweet out a beautiful song a half hour before the alarm clock goes off.I will sing the song of my people when my humans are sound asleep.I will finally catch and destroy that bird.I will learn how to change the TV channels during the good part.I will only throw up on the carpet, never on the tile floor.I will make my human chase the ball next time we play fetch.If your pets could talk, they would likely communicate these resolutions to you. New Year’s resolutions: they’re not just for humans anymore. I will dress up in costume for Halloween and go trick or treating.įunny New Year’s Resolutions for Your Dog, Cat, or Other Pet.I will share inappropriate jokes at the most awkward moment possible.I will binge-watch my favorite show while eating a pint of ice cream all by myself.
A good reason to play as many of them as you can just in case they get taken away. Netflix recently acquired developer Spry Fox, developer behind the Animal Crossing-adjacent Cozy Grove, so it's clear the streaming giant is still interested in expanding into the world of games, even if (as of August) only 1% of its user base is playing its games. Netflix and developer Tender Claws are releasing a Stranger Things VR game set to arrive in Winter 2023 on major VR platforms, the companies announced at Stranger Things Day 2022. It's unclear if the game is planned to directly tie into the show or if it's just its own thing, but either way it seems like a pretty cool way to experience the story of a fan-favourite villain. "As fans, we want this game to be very special and we are energised by the support and enthusiasm we've received from Netflix and the Stranger Things creative team." 6 All the PlayStation VR2 games Sony announced today, including The Dark Pictures Switchback. "We are awed that we get to live within the Stranger Things universe and dive into the rich inner worlds of its characters through Tender Claws' unique approach to nested worlds and immersive dreamscapes," said directors Samantha Gorman and Danny Cannizzaro shared in a joint statement. Upcoming Stranger Things VR game puts players in control of Vecna. It's also planned for all major VR platforms, though no specifics on which those are, and should be launching winter 2023, but again no more details than that. The game is described as a "pyschological horror/ action game," so presumably not one for the faint of heart. Taking on this role, you'll be invading the memories and dreams of characters from the show, and you can "harness telekinetic powers to battle humans and creatures alike" (via Eurogamer). Become an explorer of unknown realities as you form the hive mind and tame. It was released on the PlayStation Store on December 12, 2017. Strangers Things VR is being made in collaboration with Netflix from Virtual Virtual Reality developer Tender Claws, and rather than letting you play as one of the kids, this time round you're playing as season four's big bad Vecna. 2.67M subscribers Subscribe 17K 551K views 4 months ago Play as Vecna in this new Stranger Things adventure in VR. Stranger Things: The VR Experience is a first-person virtual reality adventure-horror game based on the Stranger Things web television series, and developed by Sony for the PlayStation 4. Tender Claws, the developer, promises that the game will provide. stranger to the world of video games and VR as there has been Stranger Things: The VR Experience, multiple mobile games, a mobile and console game called Stranger Things 3: The Game, and even a canceled Stranger Things game from the now-defunct Telltale Games.If you watched Stranger Things season four, took one look at Venca and thought 'god I wish that were me,' you're in luck, because Stranger Things VR makes that dream come true! Netflix has announced Stranger Things VR, a new game that will let fans of the show play as Vecna, the big bad from s eason four. Tender Claws has previously worked on such games as Virtual Virtual Reality 1 & 2, The Under Presents, Tempest, Tendar, and George in the Tub. Stranger Things VR is a psychological horror/action game developed by Tender Claws and coming to major VR platforms in Winter 2023."įor those who may not know, Vecna was the big bad of Stranger Things 4, and you can check out our breakdown of the villain, the truth about Vecna, and Vecna actor Jamie Campbell Bower breaking down the big final moment from Season 4, Part 2. BlueStacks is an app player that lets you play Android games on a PC without the need for an elaborate setup or accessories. Click the Stranger Things icon on the home screen to start playing. Complete Google sign-in (if you skipped step 2) to install Stranger Things. Invade minds and conjure nightmares in your quest to enact revenge on Eleven and Hawkins. Click to install Stranger Things from the search results. "Become an explorer of unknown realities as you form the hive mind and tame the void. "Play as Vecna in this new Stranger Things adventure in VR," the official description reads. Stranger Things VR was revealed during the Stranger Things Day 2022 celebrations with a short teaser that features the ticking grandfather clock, demogorgons, and even an appearance by Eleven.Įver want to spend a day AS vecna? now you can with Stranger Things VR coming winter 2023 to a VR headset near you! /X9gLze9ord- Stranger Things November 6, 2022 The poet gave voice to all-big or small, rich or poor. Dhan Gopal Mukerji has said that these songs transcend the mundane to the aesthetic and express all ranges and categories of human emotion. It is said that his songs are the outcome of five centuries of Bengali literary churning and communal yearning. His songs are widely popular and undergird the Bengali ethos to an extent perhaps rivalling Shakespeare's impact on the English-speaking world. Tagore influenced sitar maestro Vilayat Khan and sarodiyas Buddhadev Dasgupta and Amjad Ali Khan. Problems playing this file? See media help. Paraj conveyed to him the deep slumber that overtook one at night's end. In bhupali he seemed to hear a voice in the wind saying 'stop and come hither'. The pathos of the purabi raga reminded Tagore of the evening tears of a lonely widow, while kanara was the confused realization of a nocturnal wanderer who had lost his way. Scholars have attempted to gauge the emotive force and range of Hindustani ragas: In fact, Tagore drew influence from sources as diverse as traditional Hindusthani Thumri ("O Miya Bejanewale") to Scottish ballads ("Purano Shei Diner Kotha" from " Auld Lang Syne"). Yet about nine-tenths of his work was not bhanga gaan, the body of tunes revamped with "fresh value" from select Western, Hindustani, Bengali folk and other regional flavours "external" to Tagore's own ancestral culture. Some songs mimicked a given raga's melody and rhythm faithfully others newly blended elements of different ragas. They emulated the tonal color of classical ragas to varying extents. Influenced by the thumri style of Hindustani music, they ran the entire gamut of human emotion, ranging from his early dirge-like Brahmo devotional hymns to quasi-erotic compositions. Rabindra Sangeet merges fluidly into Tagore's literature, most of which-poems or parts of novels, stories, or plays alike-were lyricised. The name Rabindra Sangeet was first introduced by the noted Indian author, economist and sociologist Dhurjati Prasad Mukherjee in the anthology Jayanti Utsarga, published on Decemto commemorate Tagore's 70th birthday. Tagore created some six new taals, inspired by Carnatic talas, because he felt the traditional taals existing at the time could not do justice and were coming in the way of the seamless narrative of the lyrics. Lyrics and music both hold almost equal importance in Rabindra Sangeet. The music is mostly based on Hindustani classical music, Carnatic music, Western tunes and the traditional folk music of Bengal and inherently possess within them, a perfect balance, an endearing economy of poetry and musicality. and is filled with expressions of romanticism. It is characterised by its distinctive rendition while singing which, includes a significant amount of ornamentation like meend, murki, etc. Dance accompanied by Rabindra Sangeet, at Science City auditorium in Kolkata. The songs have distinctive characteristics in the music of Bengal, popular in India and Bangladesh. Tagore was a prolific composer with approximately 2,232 songs to his credit. Rabindra Sangeet ( Bengali: রবীন্দ্র সঙ্গীত pronounced ), also known as Tagore Songs, are songs from the Indian subcontinent written and composed by the Bengali polymath Rabindranath Tagore, winner of the 1913 Nobel Prize in Literature, the first Indian and also the first non-European to receive such recognition. Some speak of friendship, unity and togetherness, while others harp on God, eternity, etc.Rabindranath Tagore (right) and Indira Devi Chaudhurani (left) in Valmiki-Pratibha opera The collection of autograph poems vary in theme. Another file ‘MS 460’ includes eight poems by the Nobel laureate in his own handwriting in an address book. The file ‘MSF Autograph Poems’ contains several sets of typed poems. The polymath had composed numerous such short poems during his visits to China and Japan between 19.Īt Rabindra Bhavana, part of the Visva Bharati university campus, multiple versions of Rabindranath’s autograph-poems can be found either in the poet’s own handwriting or in typed scripts or printed forms. The book says Tagore soon perfected the craft and took it seriously which is evident in the painstaking modification of many of these poems years after they had been written. After getting the Nobel Prize in Literature in 1913 for his book of poems ‘Gitanjali’, ‘Gurudev’ had become a celebrity in Asia and Europe and was often requested by fans to compose short poems while signing autographs. To draw any plot, we need to tell the program where it can find the data and which information should go where. Personally, I prefer a white background, so I tell ggplot2 to switch its default theme to black and white: theme_set ( theme_bw ()) To activate these functions, run the following command: library ( ggplot2 )īy default, ggplot2 draws plots on a grey background. There are a couple of ways to draw a scatterplot in R.įor this tutorial we’ll use the functions in the ggplot2 package. You don’t have to compute the average Raven score per age group etc. There’s no need to group together participants by decade The basic idea behind a scatterplot is simple:Įach pair of (Age, Raven) observations is shown in an XY plane. The workhorse plot for showing the relationship between two continuous variables such as these is the scatterplot. The goal is to visualise the relationship between the self-explanatory Age variable and Raven, which contains the participants’ results on a cognitive task. To get an outline of the dataset, you can run the str() command with dat as its argument (the lines beginning with ‘#’ show the output of the command you don’t have to type this yourself): str ( dat ) # 'ame':đ63 obs. To import it into R, enter the following command at the prompt (again verbatim): dat <- read.csv ( file.choose ())Ī window will now open where you can navigate to the directory where you’ve saved the dataset. The data for this exercise are available from. Likewise if you type INSTALL.PACKAGES("ggplot2") (in caps). Make sure you type (or copy-paste) the command verbatim – if you type install.package("ggplot2") (without the s), R will return an error. This installs a (free) add-on package, ggplot2, that provides powerful plotting capabilities. At the prompt (bottom left, the line starting with ‘>’), type the following command: R itself is run on a command line RStudio provides a more organised user interface for R. R is a free but powerful environment for conducting statistical analyses and drawing graphs. In addition, the plots it produces look pretty clean and professional (I often find Excel graphs to be pig ugly, but that’s me), and it’s easier to tell you which commands you have to type at the R prompt than what you have to select and click in Excel. The main reason is that I’m most familiar with it myself. While they were free to use whatever program they wanted, I’m going to use R in this solution. This blog post is a step-by-step solution to an exercise I gave my students. I’ve decided I’m going to stress it more in my teaching. Researchers themselves or will have to communicate research data to policy makers and teachers – Since knowing how to draw a good graph is bound to be a useful skill for our students – whether they’ll become One that may not be entirely comfortable with concepts such as, say, standard deviations or confidence intervals (any casual definition of either of which is almost certainly wrong). This makes graphs – rather than numerical descriptions or significance tests – essential for presenting research results to an audience, especially one that may not be familiar with advanced statistical techniques or even is there a lot of variation or do the individual data points map closely onto the patterns? In my view, a good graph provides a reasonably accurate picture of the main patterns in the data and of how the raw data relate to these patterns – i.e. Second, while a good graph can be difficult to construct, it should – by virtue of being a good graph – be straightforward to comprehend with little guidance on the part of the author or presenter. This is unfortunate, as a good graph serves two important purposes:įirst, it can alert the researcher to aspects of the data that aren’t obvious from a purely numerical description, such as outliers, coding errors, non-linearities, and skewed distributions. When flicking through an issue of a journal on language research or when attending a conference,Ĭhances are you’ll harvest a fair number of unclear, uninformative, for-the-record-only graphs. It is geared towards readers who don’t have much experience with drawing statistical graphics and who aren’t entirely happy with their attempts in Excel. This blog post is a step-by-step guide to drawing scatterplots with non-linear trend lines in R. You'll also appreciate the five cleaning tools that make it easier to clean everything from mattresses to ceiling fans. And LG's Smart Inverter Motor provides superior suction power across all floor types. Kompressor technology compresses dirt and dust so you can keep cleaning instead of stopping to empty the dust bin. Get powerful suction, cordless convenience and the long-lasting cleaning power of LG Kompressor technology with this handy stick vacuum. With one battery, run time for each mode-Normal, Power and Turbo-is up to 40 mins, 20 mins and 6 mins respectively.Īctual run time may vary depending on operating environment and hours of use.LG CordZero Kompressor Stick Vacuum with Total Care Kit & Extra Nozzle ***Run time with Power Drive Nozzle for each mode-Normal, Power and Turbo- is up to 80 mins, 40 mins and 12 mins respectively when two batteries are used. 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These run times apply when two batteries are used, with one being charged in the vacuum cleaner and the other being directly charged by the charging station. The LG CordZero A9 is a cordless stick vacuum. *Based on LG internal test results, run time for each mode-Normal, Power, and Turbo-is up to 120 mins, 60 mins, and 14 mins, respectively. Eliminate dust from your living spaces with this 350W LG CordZero Kompressor stick vacuum. The LG CordZero All in One Auto Empty Cordless Stick Vacuum is the latest addition to the brand’s CordZero range of some of the best vacuum cleaners that are cordless stick-style vacuums, which. CordZero Kompressor Cordless Stick Vacuum with Power Punch Nozzle (A927KGMS) 699.00. With the compaction of dust and hair (by up to 2.4 times the. Kompressor Technology 2 Quick Release Batteries and Portable. The LG KOMPRESSOR technology saves you time by compressing dust and hair collected in the bin. Our Lightweight Vacuum & Advanced Filtration Gets All Surfaces. 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Despite how John talked about Mary to Sam and Dean, there were indications that their marriage was not entirely happy, and that Heaven was involved in bringing them together in order for Dean and Sam to be born, as a Cupid revealed to Sam and Dean that John and Mary couldn't stand each other initially until Heaven's intervention. Dean remembers her making tomato and rice soup for him when he was sick, and singing "Hey, Jude" to him as a lullaby. Five years later Mary would give birth to Dean on January 24, 1979, with Sam following on May 2, 1983. This involved her granting him access to her home ten years. Mary made a deal with the demon in order to resurrect John. In 1973 Azazel killed both her parents as well as John. When John asked for Mary's number, she gave it to him, despite knowing her father wouldn't approve. The two would go to Mulroney's Diner and talk. While Mary was embarrassed, John simply laughed it off, and told her she could get him a cup coffee to make it up to him. On Maafter seeing the film Slaughterhouse-Five, Mary bumped into John Winchester, knocking him down. She kept extensive journals as she traveled around with her family, learning the hunting trade until they ended up in Lawrence, Kansas. Goodbye, Mom.īorn Mary Sandra Campbell, on Decemto Samuel and Deanna Campbell. But we're so glad for the time that we had. Someone who had opinions and wasn't shy in using them. And we got to know her not just as "Mom," but. 2.27 12.21 There's Something About Mary.2.22 12.12 Stuck in the Middle (With You).2.19 12.06 Celebrating the Life of Asa Fox.2.14 8.15 Man's Best Friend with Benefits.2.5 2.21 All Hell Breaks Loose: Part One.
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